ASODE™ (Anti-Sense Oligonucleotide Development) is Autotelic Bio’s ASO new drug development system
which includes the whole processes of ASO sequence design, chemical modification, and in vitro/in vivo evaluations to derive the optimal ASO.
01.
ASO Sequence Derivation
After Setting up hot spot regions that can effectively inhibit target mRNA, we derive customized ASO sequences that act on those regions.
02.
ASO Sequence Design
The derived ASO sequences are composed of second or third-generation modified sugars with PS (phosphorothioate) backbone as the basic structure, and can be designed in various ways depending on the target.
03.
ASO Novel Molecule Derivation
The designed ASOs are synthesized in-house and then novel molecules are derived based on the designed ASOs through in vitro and in vivo evaluation stages.
Introduction of Autotelic Bio’s effective processes for deriving novel molecules
01
Target Gene Selection
02
Sequence Selection
03
ASO Design/Manufacture
04
In vitro Evaluation
05
In vivo Evaluation
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