C-Duplex™ improves brain distribution of ASOs and extends dosing intervals, offering a meaningful advantage
in patient treatment. The platform is being applied to ATB-810, our flagship neurodegenerative disease program.

C-Duplex™ Platform for Enhanced
Brain Delivery of ASO

C-Duplex™

01.

Superior Brain Distribution

• Increases cell permeability
• Improves knockdown (K/D) efficiency
• Enhances brain distribution

02.

Superior Dosing Convenience

• Extends dosing intervals
• Reduces toxicity